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Chemotherapy Agents Used to Treat Gynecologic Cancers Classifcation Agent Side Effects Alkylating agent Carboplatin Myelosuppression, nausea and vomiting, hypersensitivity reactions; much less renal toxicity than cisplatin Cisplatin Myelosuppression, nausea and vomiting, hypomagnesemia, hypersensitivity reactions, nephrotoxicity, neurotoxicity, ototoxicity Cyclophosphamide Myelosuppression, nausea and vomiting, alopecia, hemorrhagic cystitis, secondary malig- nancy, testicular/ovarian failure Ifosfamide Myelosuppression, nausea and vomiting, alopecia, hemorrhagic cystitis, neurotoxicity Antibiotic agent Bleomycin Hypersensitivity reactions; pulmonary, renal, and hepatic toxicity; photosensitivity; fever and chills Doxorubicin Myelosuppression, nausea and vomiting, mucositis, alopecia, cardiac toxicity, radiation recall, red urine, photosensitivity Epirubicin Myelosuppression, nausea and vomiting, mucositis, diarrhea, alopecia, radiation recall, red urine, cardiac toxicity Liposomal doxoru- Myelosuppression, nausea and vomiting, mucositis, alopecia, hand-foot syndrome, automotive- bicin diac toxicity, purple urine, photosensitivity Mitomycin Myelosuppression, nausea and vomiting, mucositis, anorexia, alopecia, pulmonary and renal toxicity, fatigue Antimetabolite agent 5-fuorouracil Myelosuppression, nausea and vomiting, mucositis, diarrhea, anorexia, alopecia, darken- ing of veins, photosensitivity Gemcitabine Myelosuppression, nausea and vomiting, mucositis, rash, fu-like signs Methotrexate Myelosuppression, nausea and vomiting, mucositis, renal toxicity, photosensitivity, hepatic toxicity, neurotoxicity Aromatase inhibitor Letrozole Myelosuppression, scorching fashes, bone ache, headache, chest ache, arthralgia, dyspnea, fatigue Epipodophyllotoxin Etoposide Myelosuppression, nausea and vomiting, mucositis (at high doses), anorexia (at excessive group doses), hypersensitivity reactions, alopecia, hypotension, secondary malignancies Experimental agent Bevacizumab Diarrhea, hypertension, hemorrhage, proteinuria, congestive heart failure, leucopenia, thromboembolism, hyponatremia Plant alkaloid Irinotecan Myelosuppression, diarrhea, alopecia Vinorelbine Myelosuppression, nausea and vomiting, constipation, alopecia, neurotoxicity Selective estrogen Tamoxifen Nausea and vomiting, hypercalcemia, menstrual irregularity, vaginal discharge/bleeding, receptor modulator hot fashes Taxane Docetaxel Myelosuppression, nausea and vomiting, mucositis, hypersensitivity reactions, alopecia, fuid retention, skin and nail changes, neurotoxicity Paclitaxel Myelosuppression, mucositis, diarrhea, hypersensitivity reactions, alopecia Topoisomerase-I Topotecan Myelosuppression, mucositis, diarrhea, alopecia, headache inhibitor Note. 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